Subjective memory complaints in the preclinical presentations of

 
   Lead Investigator:    Samantha John
   Institution      :    Emory University Alzheimer's Disease Research Cent
   E-Mail           :    sejohn@emory.edu
   Proposal ID      :    853


   Publications:


1  John SE, Evans SA, Hanfelt J, Loring DW, Goldstein FC
   Disparities in subjective memory complaint in African Americans and Caucasians
   2019   Abstract  J Geriatr Psychiatry Neurol , 

   ACCEPTED



2  John SE, Evans SA, Hanfelt J, Loring DW, Goldstein FC
   Disparities in subjective memory complaint in African Americans and Caucasians
   2018   Journal Article  J Am Geriatr Soc , 

   SUBMITTED





   Proposal Description:
   1) To identify the unique factors and clinical presentations across both          Caucasian and African American patient samples that motivate patients to seek     out neuropsychological testing and longitudinal disease monitoring                2) To assess the relationship between subjective cognitive complaints and         functional changes and objective declines in neuropsychological functioning       over time                                                                         3) To explore the relationship between subjective cognitive changes and           objective neuropsychological changes to see if ?memory complaints? are            colloquially used to describe diverse patterns of cognitive change and if this    relationship is consistent across Caucasian and African American samples.         Much of the research on subjective memory complaints has focused on Caucasian     samples however, African Americans are at a greater risk for developing           Alzheimer?s disease. African Americans also tend to present for evaluation at     later stages of disease and tend to receive a diagnosis of Alzheimer?s disease    at lower rates than their Caucasian counterparts. Subjective memory complaints    have been linked to diagnostic conversion as well as declines on measures of      verbal episodic memory. The relationship between subjective complaints and        judgments of functioning and declines in other domains of functioning is not      well understood and may differ as a result of biomarker status or other           historical or demographic factors. Finally, the relationship between subjective   complaints and diagnostic status is muddled by the fact that diagnostic           criteria take into account the presence of subjective declines. Therefore, we     are proposing to study the relationship between subjective memory complaints      and actual objective cognitive decline over time, independent of diagnostic       status. We hypothesize that the